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Scientific Publication Citing Dragonfly

Cholesterol removal via cyclodextrin-decoration on cellulose nanocrystal (CNC)-grafted poly(HEMA-GMA) nanocomposite adsorbent

Kazim Kose (1,2), Miran Mavlan (3), Lokman Uzun (4), Jeffry P. Youngblood (2)
Cellulose, 28, January 2021: 471–487. DOI: 10.1007/s10570-020-03534-7

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Keywords

Cellulose nanomaterial; Cyclodextrin; Cholesterol; Low density lipoprotein; Removal

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Abstract

Glycidyl methacrylate (GMA) was grafted to cellulose nanocrystals (CNCs) using hydroquinone resulting in a crosslinkable nanoparticle. 2-Hydroxyethyl methacrylate (HEMA) was used to polymerize this nanoparticle to obtain a polymeric structure with a bridging CNC structure to which cyclodextrin (CD) was attached in order to better capture hydrophobic biomolecules. X-Ray Microscopy and nuclear magnetic resonance methods provided the main characterization data proving the successful modification process. This CD-modified nanocomposite adsorbent was used for the removal of cholesterol and lowdensity lipoprotein for the first time. Adsorption performance in a continuous system was * 99% for both cholesterol and low-density lipoprotein with agreement between experimental data and mathematical models performed. Overall, results indicate that cyclodextrin modified poly(HEMA-GMA-g-CNC) is a promising material for use as an adsorbent for biological and biomedical applications.

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How Our Software Was Used

Dragonfly was used to visualize, analyze, and quantify the fibers of the polymeric hydrogel sample, the porosity and pore network

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Author Affiliation

(1) Department of Chemistry, Hitit University, 19040 Çorum, Turkey.
(2) Department of Materials Engineering, Purdue University, West Lafayette, IN 47906, USA.
(3) Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA.
(4) Department of Chemistry, Hacettepe University, 06800 Ankara, Turkey.

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