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Strontium release from Sr2+-loaded bone cements and dispersion in healthy and osteoporotic rat bone

Rohnke M(a), Pfitzenreuter S(b), Mogwitz B(b), Henß A(b), Thomas J(c), Bieberstein D(c), Gemming T(c), Otto SK(b), Ray S(d), Schumacher M(e), Gelinsky M(e), Alt V(f).
Journal of Controlled Release. 2017 Sep 28;262:159-169. doi: 10.1016/j.jconrel.2017.07.036. Epub 2017 Jul 27.


Publication Date

September 28, 2017.


Keywords

Bone; Drug diffusion; Drug loaded biomaterials; Drug mobility; Finite element calculation; ToF-SIMS; Two phase model


Abstract

Drug functionalization of biomaterials is a modern and popular approach in biomaterials research. Amongst others this concept is used for the functionalization of bone implants to locally stimulate the bone healing process. For example strontium ions (Sr2+) are administered in osteoporosis therapy to stimulate bone growth and have recently been integrated into bone cements. Based on results of different analytical experiments we developed a two-phase model for the transport of therapeutically active Sr2+-ions in bone in combination with Korsmeyer-Peppas kinetics for the Sr2+ release from bone cement…


Author Information

(a)Institute of Physical Chemistry, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
(b)Institute of Physical Chemistry, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
(c)IFW Dresden, Institute for Complex Materials, Helmholtzstrasse 20, 01069 Dresden, Germany.
(d)Laboratory of Experimental Trauma Surgery, Justus-Liebig-University, Aulweg 128, 35392 Giessen, Germany.
(e)Centre for Translational Bone, Joint and Soft Tissue Research, Medical Faculty and University Hospital, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
(f)Laboratory of Experimental Trauma Surgery, Justus-Liebig-University, Aulweg 128, 35392 Giessen, Germany; Department of Trauma Surgery, University Hospital Giessen-Marburg GmbH, Campus Giessen, Rudolf-Buchheim-Strasse 7, 35385 Giessen, Germany.


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